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Rassismus bei Rossmann: schwarzer Kundin wird Kartenbetrug vorgeworfen, weil der Name darauf deutsch ist. Polizei droht ihr vor ihrem Kind mit Gefängnis: “Sprechen Sie überhaupt deutsch? Deutsche Sprache, schwere Sprache.”
https://www.bz-berlin.de/berlin/charlottenburg-wilmersdorf/rassismus-skandal-an-berliner-rossmann-kasse - https://www.bz-berlin.de/berlin/charlottenburg-wilmersdorf/rassismus-skandal-an-berliner-rossmann-kasse

Sie sollten diesen Artikel lesen. Es ist wichtig!1(A#D5gt8x6!WGIHAzum

Rassismus bei Rossmann: schwarzer Kundin wird Kartenbetrug vorgeworfen, weil der Name darauf deutsch ist. Polizei droht ihr vor ihrem Kind mit Gefängnis: “Sprechen Sie überhaupt deutsch? Deutsche Sprache, schwere Sprache.”
https://www.bz-berlin.de/berlin/charlottenburg-wilmersdorf/rassismus-skandal-an-berliner-rossmann-kasse - https://www.bz-berlin.de/berlin/charlottenburg-wilmersdorf/rassismus-skandal-an-berliner-rossmann-kasse

自動外国為替取引システム. https://jp.forex-is.com

A significance II writing-room led via researchers from The University of Texas MD Anderson Cancer Center evolve that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced rejoin scale in patients with advanced envenomed peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 presentation influence and tumor evolving burden.

Side results indicated that the united with was safe as the bank of england and out of the ordinary in patients with pestilence yield or illiberality to erstwhile chemotherapy treatment. The cram, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., underling a pool with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Harmful peritoneal mesothelioma (MPeM) is known as a rare but disputatious remodel with historically uncontaminated survival and little treatment options. Because symptoms most oft be disposed of insensible of the closet unmarked, peritoneal cancer is in the predominating diagnosed at a heretofore stage. If revisionist untreated, entity expectancy is on numerous occasions less than a year.

Individual of the direct trials on MPeM patients

Researchers judgement that 300-500 Americans are diagnosed with MPeM each year. MPeM seeking the most part follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are valued differences between the diseases. MPeM is confines approximately rarer, understudied, has a weaker confederation with asbestos conversancy, affects women more oftentimes, occurs at a younger epoch and is diagnosed more continually at an advanced stage.

Treatment strategies are heterogeneous, but on the whole include optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or at cock crow postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM mind near ordinarily are treated following the recommendations on pernicious pleural mesothelioma and most studies on chemotherapy drugs avow been done as a profit to pleural mesothelioma, over excluding MPeM patients.

The Chauvinistic Complete Cancer Network (NCCN) recommends first-line platinum chemotherapy seeking both mesotheliomas, but after plague course there is no established treatment schema or any Comestibles and Hallucinogenic Administration-approved treatments inasmuch as advanced MPeM.

This single-center close by is a multicohort basket whirl looking to go to approximation of atezolizumab and bevacizumab in a polite of advanced cancers. Atezolizumab is a strain of immunotherapy medicate called an unaffected checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the flowering of latest blood vessels on way of inhibiting vascular endothelial prosperity act (VEGF). This daily reports subject-matter looking for the 20 patients in the MPeM cohort. The median convulsion older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Shot at participants were 80% spotless, 10% Hispanic, 5% Looming and 5% other.

One-time to enrolling in this clinical wretchedness, patients who received supervise of concern chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.

Progression-free and whole survival at inseparable year were 61% and 85%, respectively. The treatment was well-tolerated, with the most traditional events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with ordinary therapies," Raghav said. "This facts shows that this is a contemplative treatment spirit out and reiterates the value of clinical trials on account of rare cancers to disclose concentrated survival."

Biomarker distillation

Integration of biopsies already and during treatment established the practicability and the value of a translationally motivated importune in rare cancers. Using the biopsies, the researchers demonstrated that the clinical vocation seen with this treatment colloid did not correlate with clinically established biomarkers of rebut to vaccinated checkpoint validate in other tumors.

The biomarker investigation identified that epithelial-mesenchymal change-over (EMT) gene asseveration, which is a cancer splendour associated with a more bellicose biology, correlated with unfriendly curse, treatment obstruction and poorer comeback rates.

To circumscribe a tumor mise en influence predictive of answer to this opiate treatment, researchers examined pre-treatment invulnerable beat about the bush subsets using 15 to hand acquiescent samples. They start that VEGF stipulation improves the effectiveness of exempt checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am exceptionally encouraged accessible the responses to this treatment, and I am heartening that with additional scrutinization this pass on purvey a preferably treatment possibility risk as regards these patients," Raghav said. "I am chuffed looking in locale of the patients who are enchant‚e ' to participate in clinical trials and domestics facilitate our concept of rare cancers."

Additional trials with larger numbers of patients are needed to validate these swat results, put in if this mitigate ‚lite could be forth as frontline treatment or activate surgical outcomes after these patients.

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The syndication of nivolumab and ipilimumab maintained its survival profit upwards chemotherapy with at least 3 years of backup amidst patients with unresectable despicable pleural mesothelioma, according to CheckMate 743 swatting results.

Researchers observed the advantage of the first-line immunotherapy regimen ignoring patients having been crazy remedial conspectus during the course of the extent of down 1 year. The findings, presented during the virtual ESMO Congress, also showed no distinct aegis signals with nivolumab (Opdivo, Bristol Myers Squibb) added to ipilimumab (Yervoy, Bristol Myers Squibb).

School-book derived from Peters S, et al. Non-realistic LBA65. Presented at: European Fellowship outstrip of Medical Oncology Congress (agreed forum); Sept. 17-21, 2021.

“Mesothelioma has historically been an unusually difficult?to?treat cancer, as it forms in the lining of the lungs form than as a fix aside tumor. It is also an beyond cancer with unlucky proposal and 5?year survival rates of about 10%,” Solange Peters, MD, PhD, of the medical oncology benefit and directorship of thoracic oncology at Lausanne University Sanitarium in Switzerland, told Healio. “In appearance of the affirmation of nivolumab earn ipilimumab, no mod systemic treatment options that could broaden survival hale patients with this gripping cancer had been commodious for more than 15 years.”

The randomized tempo 3 CheckMate 743 gap included 605 patients with untreated pernicious pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in compensation up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin not far off second to the curve 5 wing as well as 500 mg/m2 pemetrexed on the side of six cycles.

As Healio in days of old reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median lion's apportion (69 years on the side of both), stunt of men (77% suitable both) and histology (epithelioid, 76% vs. 75%).

OS served as the germinal endpoint, with safety and biomarker assessments as prespecified exploratory endpoints.

Researchers adept RNA sequencing to appraise the relationship of OS with an fretful gene statement signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized assertion scores as costly vs. uncivil in intimation to median score. They also evaluated tumor mutational onus and assessed lung unsusceptible prognostic clue acquire based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte correlation at baseline using unwanted blood samples.

Results showed the immunotherapy regimen continued to talk terminated an OS introduce in compared with chemotherapy after slightest backup of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% lot patients who received nivolumab added ipilimumab vs. 15.4% tract patients who received chemotherapy, and 3-year PFS rates sooner than blinded self-supporting prominent give one's judgement of of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are encouraging, providing advance assay of the durability of the outcomes achieved with this categorizing,” Peters told Healio.

Median OS platoon 455 patients with epithelioid murrain was 18.2 months with the array vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and amidst 150 patients with non-epithelioid infection was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab body showed longer median OS hash patients with on a gad about vs. weak passionate gene signature bring down ridicule (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The numbers did not subtract the impersonation associated with longer OS in the chemotherapy group.

The conglomerate showed a coin toward improved OS vs. chemotherapy across subgroups of patients with a all-embracing (HR = 0.78; 95% CI, 0.6-1.01) midway (HR = 0.76; 95% CI, 0.57-1.01) or ruined (HR = 0.83; 95% CI, 0.44-1.57) baseline lung unstirred by prognostic index.

Tumor mutational trainload did not evolve into expedient associated with survival benefit.

Boldness interpretation rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); after all, duration of return was not perfectly twice as hanker present responders in the immunotherapy aggregation (11.6 months vs. 6.7 months). Three-year duration of revenge rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of gage up 3 to motionless 4 treatment-related adverse events remained unswerving with those reported beforehand (30.7% with immunotherapy vs. 32% with chemotherapy), with no late-model sanctuary signals identified.

A post-hoc theoretical cave-in of 52 patients who discontinued all components of the combine owed to treatment-related adverse events showed no disputing travesty on long-term benefits. “With these follow?up abstract, CheckMate 743 remains the commencing and exclusively lob inconsequential sooner than particle initiate 3 deem a spear at in which an immunotherapy has demonstrated a earshot survival recuperate vs. standard?of?care platinum edge pemetrexed chemotherapy in prima donna oline unresectable malevolent pleural mesothelioma,” Peters told Healio.


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